Change in the functional activity of fibroblasts in patients with coronavirus infection (history of SARS-CoV-2)
https://doi.org/10.32885/2220-0975-2024-1-67-77
Abstract
Introduction. In the genesis of the formation of somatic dysfunction, the leading role is given to adaptive reactions on the part of the body as a whole and connective tissue in particular. The main cells of connective tissue are fibroblasts, which have an important role in the formation of the structural and functional characteristics of connective tissue. There is an opinion that after a coronavirus infection, the adaptive activity of fibroblasts changes in response to external influences.
The aim is to study changes in the functional activity of fibroblasts during a simulated compression effect on a culture of fibroblasts obtained from patients who suffered coronavirus infection 3–6 months before the experiment.
Materials and methods. Under experimental conditions (in vitro), compression conditions were simulated in relation to a culture of fibroblasts taken from patients who had suffered a coronavirus infection (with a history of SARS-CoV-2) and patients who had no history of coronavirus infection.
Results. Under experimental conditions, it was found that fibroblasts from patients who have suffered coronavirus infection have altered functional activity, manifested by a decrease in secreted glycosaminoglycans, elastin and collagen in response to in vitro modeling of the compression factor.
Conclusion. The established response of fibroblasts to compression allows us to justify the need for priority elimination of this factor as part of osteopathic correction in patients who have suffered coronavirus infection during treatment and rehabilitation.
About the Authors
I. A. Aptekar
Tyumen Institute of Osteopathic Medicine; Tyumen Institute of Manual Medicine
Russian Federation
Russian Federation
Igor A. Aptekar - Cand. Sci. (Med.), Associate Professor, General Manager of Tyumen Institute of Manual Medicine; General Manager of Tyumen Institute of Osteopathic Medicine, osteopathic physician, neurologist, manual therapist.
7-a ul. Popova, Tyumen, 625048; 7-f ul. Popova, Tyumen, 625048
E. G. Kostolomova
Tyumen State Medical University
Russian Federation
Russian Federation
Elena G. Kostolomova - Cand. Sci. (Biol.), Associate Professor of the Department of Microbiology, Institute of Pharmacy, Tyumen State Medical University.
54 ul. Odesskaya, Tyumen, 625023
Scopus Author ID: 44061604000
Yu. G. Sukhovey
Tyumen branch of the Institute of Fundamental and Clinical Immunology
Russian Federation
Russian Federation
Yuri G. Sukhovey - Dr. Sci. (Med.), Professor, Director of the Tyumen branch of the Research Institute of Fundamental and Clinical Immunology.
5/2 ul. Kotovskogo, Tyumen, 625027
V. I. Aptekar
Tyumen Institute of Manual Medicine; Tyumen State Medical University
Russian Federation
Russian Federation
Vladislav I. Aptekar - postgraduate student of the Department of Human Anatomy, Topographic Anatomy and Operative Surgery with a Course of Osteopathy, Institute of Fundamental Medicine, Tyumen State Medical University; osteopathic physician, Tyumen Institute of Manual Medicine.
7-f ul. Popova, Tyumen, 625048; 54 ul. Odesskaya, Tyumen, 625023
E. V. Abramova
Tyumen Institute of Manual Medicine; Tyumen State Medical University
Russian Federation
Russian Federation
Elena V. Abramova - Cand. Sci. (Med.), Associate Professor of the Department of Childhood Diseases and Outpatient Pediatrics, Institute of Motherhood and Childhood, Tyumen State Medical University; the Head of the Osteopathic Children′s Tyumen Institute of Manual Medicine, osteopathic physician, pediatrician.
7-f ul. Popova, Tyumen, 625048; 54 ul. Odesskaya, Tyumen, 625023
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For citations:
Aptekar I.A., Kostolomova E.G., Sukhovey Yu.G., Aptekar V.I., Abramova E.V. Change in the functional activity of fibroblasts in patients with coronavirus infection (history of SARS-CoV-2). Russian Osteopathic Journal. 2024;(1):67-77. (In Russ.) https://doi.org/10.32885/2220-0975-2024-1-67-77
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