rojournalРоссийский остеопатический журналRussian Osteopathic Journal2220-09752949-3064All-Russian Public Organization «Russian Osteopathic Association» (ROsA)10.32885/2220-0975-2023-4-93-103rojournal-513Research ArticleЛЕКЦИИLECTURESПатофизиологические аспекты микрогравитации и гравитационной терапии при сердечно-сосудистых заболеванияхPathophysiological aspects of microgravity and gravity therapy in cardiovascular diseaseshttps://orcid.org/0000-0001-9579-2925ПерешеинА. В.PeresheinA. V.

Андрей Владимирович Перешеин, ассистент

кафедра патологической физиологии

603005

пл. Минина и Пожарского, д. 10/1

Нижний Новгород

Andrey V. Pereshein, Assistant

Pathophysiology Department

603005

bld. 10/1 sq. Minin and Pozharsky

Nizhny Novgorod

https://orcid.org/0000-0003-1211-1720КузнецоваС. В.KuznetsovaS. V.

Светлана Вадимовна Кузнецова, канд. мед. наук, доцент

кафедра патологической физиологии

603005

пл. Минина и Пожарского, д. 10/1

Нижний Новгород

Svetlana V. Kuznetsova, Cand. Sci. (Med.), Associate Professor

Pathophysiology Department

603005

bld. 10/1 sq. Minin and Pozharsky

Nizhny Novgorod

ПетроваД. А.PetrovaD. A.

Дарья Алексеевна Петрова, студентка

лечебный факультет

603005

пл. Минина и Пожарского, д. 10/1

Нижний Новгород

Dar′ya A. Petrova, student

Medical faculty

603005

bld. 10/1 sq. Minin and Pozharsky

Nizhny Novgorod

https://orcid.org/0000-0001-7228-344XПотёминаТ. Е.PoteminaT. E.

Татьяна Евгеньевна Потёмина, докт. мед. наук, профессор, заведующая кафедрой

кафедра патологической физиологии

603005

пл. Минина и Пожарского, д. 10/1

Нижний Новгород

Scopus Author ID: 23474598000

Tatyana E. Potemina, Dr. Sci. (Med.), professor, Head of Department

Pathophysiology Department

603005

bld. 10/1 sq. Minin and Pozharsky

Nizhny Novgorod

Scopus Author ID: 23474598000

tat_potemina@mail.ruПриволжский исследовательский медицинский университетРоссияPrivolzhsky Research Medical UniversityRussian Federation2023311220230493103Copyright © Перешеин А.В., Кузнецова С.В., Петрова Д.А., Потёмина Т.Е., 20232023Перешеин А.В., Кузнецова С.В., Петрова Д.А., Потёмина Т.Е.Pereshein A.V., Kuznetsova S.V., Petrova D.A., Potemina T.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rojournal.elpub.ru/jour/article/view/513

   Проблематика последствий современного малоподвижного образа жизни, постельного режима и изменений, наблюдаемых в пожилом возрасте, демонстрирует сходные механизмы развития с явлениями детренированности в космосе из-за гравитационной депривации, которые трактуются как нарушения механотрансдукции и многими авторами рассматриваются в свете патофизиологии неподвижности. Теория тенсегрити может быть основой понимания значения внешних и внутренних механических сил, влияющих на биологический контроль на молекулярном и клеточном уровнях в условиях, связанных с резким и устойчивым исчезновением сигнала гравитационного вектора. Микрогравитация вызывает серьезную потерю плотности костей и силы скелетных мышц, ухудшение состояния сердечно-сосудистой системы, ослабление иммунной системы и другие нарушения. Воздействие на организм человека с лечебной и профилактической целью различными по величине параметрами искусственной силы тяжести является современной и высокоэффективной технологией восстановительной медицины.

   Целью лекции является обобщение наиболее важных выводов об эффектах и патогенетических механизмах гравитационной терапии различных заболеваний, в основном сосудистых патологий, по данным научной литературы.

   Deconditioning in space from gravity deprivation, the problems of the consequences of modern sedentary lifestyle, bed rest and changes observed in sedentary aging demonstrate similar mechanisms of development, which are interpreted as disorders of mechanotransduction. Tensegrity theory provides the framework for understanding how external and internal mechanical forces influence biological control at the molecular and cellular levels in conditions associated with a sharp and steady disappearance of the gravitational vector signal. Microgravity causes pathologies such as severe loss of bone density and skeletal muscle strength, loss of functional capacity of the cardiovascular system, immune system and other disorders. The effect on the human body for therapeutic and preventive purposes with various parameters of artificial gravity is a modern and highly effective technology of restorative medicine.

   The aim of this lecture is to summarize the most important findings about the effects of gravitational therapy in different, mainly vascular based pathologies according to literary sources.

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The authors declare that there are no conflicts of interest present.