rojournalРоссийский остеопатический журналRussian Osteopathic Journal2220-09752949-3064All-Russian Public Organization «Russian Osteopathic Association» (ROsA)10.32885/2220-0975-2022-4-126-144rojournal-428Research ArticleОБЗОРЫREVIEWSРегуляторное действие пероксидных анион-радикалов на процессы остеогенезиса и костного ремоделирования: обзор литературыElectron-donor and regulatory effects of superoxide anion radicals on the processes of osteogenesis and bone remodeling: literature reviewРахманинЮ. А.RakhmaninYu. A.

Юрий Анатольевич Рахманин, докт. мед. наук, профессор, академик РАН, заслуженный деятель науки РФ, главный научный сотрудник

РИНЦ Author ID: 789791

Scopus Author ID: 6603473039

121099, Москва, Новый Арбат, д. 32

Yuri A. Rakhmanin, Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, Chief Researcher

РИНЦ Author ID: 789791

Scopus Author ID: 6603473039

bld. 32 ul. Novyy Arbat, Moscow, 121099

https://orcid.org/0000-0003-3097-8889ФесюнА. Д.FesyunA. D.

Анатолий Дмитриевич Фесюн, докт. мед. наук, директор

121099, Москва, Новый Арбат, д. 32

Anatoly D. Fesyun, Dr. Sci. (Med.), Director 

bld. 32 ul. Novyy Arbat, Moscow, 121099

https://orcid.org/0000-0002-8750-0686СтехинА. А.StekhinA. A.

Анатолий Александрович Стехин, канд. техн. наук, ведущий научный сотрудник

РИНЦ Author ID: 837609

Scopus Author ID: 2342631200

121099, Москва, Новый Арбат, д. 32

Anatoly A. Stekhin, Cand. Sci. (Tech.), Leading Researcher

РИНЦ Author ID: 837609

Scopus Author ID: 2342631200

bld. 32 ul. Novyy Arbat, Moscow, 121099

Stekhin-aa@mail.ruhttps://orcid.org/0000-0002-8766-2773ЯковлеваГ. В.YakovlevaG. V.

Галина Васильевна Яковлева, канд. техн. наук, старший научный сотрудник

РИНЦ Author ID: 865322

Scopus Author ID: 55863873400

121099, Москва, Новый Арбат, д. 32

Galina V. Yakovleva, Cand. Sci. (Tech.), Senior Researcher

РИНЦ Author ID: 865322

Scopus Author ID: 55863873400

bld. 32 ul. Novyy Arbat, Moscow, 121099

Национальный медицинский исследовательский центр реабилитации и курортологии Минздрава РоссииРоссияNational Medical Research Center for Rehabilitation and Balneology of the Ministry of Health of RussiaRussian Federation20221712202204126144Copyright © Рахманин Ю.А., Фесюн А.Д., Стехин А.А., Яковлева Г.В., 20222022Рахманин Ю.А., Фесюн А.Д., Стехин А.А., Яковлева Г.В.Rakhmanin Y.A., Fesyun A.D., Stekhin A.A., Yakovleva G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rojournal.elpub.ru/jour/article/view/428

Представлен анализ научных публикаций о регуляторном влиянии пероксидных анион-радикалов и электронной активации организма на функцию остеогенеза и сопряженные системы организма по следующим источникам информации: база данных Scopus, MEDLINE, Web of Science, eLibrary.ru, Google Academy — на наличие рецензируемых оригинальных и обзорных публикаций по ключевым словам: остеогенез (osteogenesis), костно-мышечная система (musculoskeletal system), реоксигенация (reoxygenation), гормональные регуляторы (hormonal regulators), электрон-донорная активность (electron-donor activity), фаза ассоциированной воды (associated water phase), реабилитация (rehabilitation), на основании которых были сформированы поисковые фразы по теме исследования. Основываясь на ряде доказательных научных исследований по регуляторному влиянию пероксидных анион-радикалов и электронной активации на биологические процессы (изменение функционального состояния печени, гематологические показатели, макро- и микроэлементный состав жидких сред и органов животных, течение репаративных процессов в поврежденных тканях), предложен биофизический механизм системного гомеостатического действия кислородных анион-радикалов. Данный механизм заключается в антигипоксическом и детоксицирующем действии при реоксигенации ишемизированных тканей, в повышении пролиферативной активности и сдвиге регуляторов остеогенеза (система sRANKL-OPG) в сторону остеопротегерина. Одновременно происходят процессы связывания внутриклеточного свободного кальция и микроэлементов в остеобластах, активации макрофагальной реакции, неоангиогенеза и восстановления миелоидной ткани в области поломки кости. Показано, что использование мицеллярного механоактивированного углекислого кальция как источника формирования пероксидных анион-радикалов в водной среде приводит к снижению редокс-состояния и стабилизации рН клеток, активации митохондриальной активности, сопровождаемой интенсификацией обмена веществ, включая обмен микро- и макроэлементов, улучшению функций системы антиоксидантной защиты и неспецифического иммунитета организма, стабилизации физиолого-биохимических показателей и функционального состояния внутренних органов.

The analysis of scientific publications on the regulatory effect of peroxide anion radicals and electronic activation of the body on the function of osteogenesis and associated systems of the body is presented according to the following information sources: Scopus database, MEDLINE, Web of Science, eLibrary.ru, Google academy for the availability of peer-reviewed original and review publications on the key words: osteogenesis, musculoskeletal system, reoxygenation, hormonal regulators, electron-donor activity, associated water phase, rehabilitation, on the basis of which search phrases on the research topic were formed. Based on a number of evidencebased scientific studies on the regulatory effect of peroxide anion radicals and electronic activation on biological processes (changes in the functional state of the liver, hematological parameters, macro- and microelement composition of liquid media and animal organs, the course of reparative processes in damaged tissues), a biophysical mechanism of systemic homeostatic action of oxygen anion radicals is proposed. This mechanism consists in antihypoxic and detoxifying action during reoxygenation of ischemic tissues, in increasing proliferative activity and shifting osteogenesis regulators (sRANKL-OPG system) towards osteoprotegerin. At the same time, the processes of binding of intracellular free calcium and trace elements in osteoblasts, activation of the macrophage reaction, neoangiogenesis and restoration of myeloid tissue in the area of bone breakdown occur. It is shown that the use of micellar mechanoactivated calcium carbonate as a source of formation of peroxide anion radicals in an aqueous medium leads to a decrease in the redox state and stabilization of cell pH, activation of mitochondrial activity accompanied by intensification of metabolism, including the exchange of micro- and macroelements, improvement of the functions of the antioxidant defense system and nonspecific immunity of the body, stabilization of physiological and biochemical parameters and the functional state of internal organs. 

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The authors declare that there are no conflicts of interest present.